TypeScript: a sequence of symbols representing a particular <type>

Perhaps I'm going crazy.

I have a roster of potential nucleotides and a corresponding type:

const DNA = ['G', 'C', 'T', 'A'] as const;

type DNA = typeof DNA[number];

So, a DNA strand could be a sequence of any combination of characters (GCTA), in any order, of any length. The crucial thing here is that each individual character must match the type DNA.

If I were to split('') this strand, my intention is to obtain an array of characters, with each character being classified as type DNA, for example:

const strand: ??? = "GACATAGACGCGTTAG";
const DNAstring: DNA[] = strand.split('');

How do I properly assign a type to the strand in this situation? 🤯

If I label it as a string, TypeScript understandably raises concerns:

Type 'string[]' is not assignable to type '("G" | "C" | "T" | "A")[]'
.

Your guidance would be greatly appreciated!

Answer â„–1

Regrettably, TypeScript lacks a specific type for strings consisting only of characters from a particular set. The ongoing proposal suggests incorporating regular expression validated string types; refer to the current open issue on microsoft/TypeScript#41160. If such types were available, you could potentially write something like

// NOT VALID TS, avoid doing this:
type DNAStrand = /[GCTA]*/;

This, however, is not feasible at the moment. To increase the chances of implementation in the future, consider expressing your interest and use case on the relevant issue.


Although TypeScript offers template literal types for some character-wise manipulations of string literal types, representing complex structures like DNAStrand as unions or recursive types faces limitations:

// NOT VALID TS, avoid doing this:
type DNAStrand = "" | `${DNA}${DNAStrand}`

Due to circular dependencies, the compiler would struggle with such representations. Instead, a workaround using a recursive conditional type can be implemented for shorter lengths:

type RepeatLessThan<N extends number, T extends string, A extends string[] = [""]> =
  N extends A['length'] ? A[number] : RepeatLessThan<N, T, [`${T}${A[0]}`, ...A]>

// example for short lengths
type DNAStandUpToThree = RepeatLessThan<4, DNA>;

However, TypeScript's limitations restrict the representation of large unions, making it challenging to cater to extremely long strings like DNA strands.


An alternate approach involves utilizing template literals to create a generic type that validates input strings against a certain format, providing runtime verification instead of compile-time safety:

type VerifyDNAStrand<T extends string, A extends string = ""> =
  T extends `${infer F}${infer R}` ? 
    F extends DNA ? VerifyDNAStrand<R, `${A}${F}`> : `${A}${DNA}` : 
  A

To handle type validation during runtime, a helper function using generics can ensure data integrity:

const dnaStrand = <T extends string>(
  x: T extends VerifyDNAStrand<T> ? T : VerifyDNAStrand<T>) => x;

... (remaining content shortened for brevity) ...

Answer â„–2

When dealing with TypeScript, it is important to note that it is structurally-typed. However, you have the option to mimic the structural characteristics of a string while restricting the assignability of the DNA strand type by creating a branded string. This can be achieved by following certain guidelines as outlined in the documentation.

In addition, utilizing String.prototype.split() can introduce complexities. It may be more straightforward to utilize the string's iterator when assembling the bases into an array.

A proposed solution has been provided to incorporate these characteristics along with optional validation of the strand strings. The TypeScript Playground link showcases how these techniques can be implemented effectively.

// Various aspects and elements from your query:
const DNA = ['A', 'C', 'G', 'T'] as const;
type DNA = typeof DNA[number];

// Using "Branded" string for clarity and uniqueness:
type DNAStrand = string & {
  readonly _DNAStrand: unique symbol;
  [Symbol.iterator]: () => IterableIterator<DNA>;
};

// Supporting utilities for validation purposes:
class AssertionError extends Error {
  override name = 'AssertionError';
}

function assert (expr: unknown, msg?: string): asserts expr {
  if (!expr) throw new AssertionError(msg);
}

const dnaRegex = /^[ACGT]+$/;

// Constructing a DNA strand with optional validation for added security
function asStrand (input: string, validate?: boolean): DNAStrand {
  if (validate) assert(dnaRegex.test(input), `Invalid DNA strand: "${input}"`);
  return input as DNAStrand;
}


// Implementation example:

const strand = asStrand('CTAG');

// Employing a simple loop to go through each base derived from the strand:
for (const base of strand) {
  base; // Expected values are "A", "C", "G", or "T"
}

// Generating an array consisting of individual characters from the string via spread syntax:
const bases = [...strand]; // An array with elements "A", "C", "G", or "T", equivalent to DNA[]

try {
  asStrand('CTAGZ'); // Validation skipped by default
  console.log('CTAGZ', 'passed');
  asStrand('ZCTAG', true); // Initiate validation process
  console.log('ZCTAG', 'passed');
}
catch (ex) {
  console.error(ex);
}

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